Xiaojian Shao (邵晓剑)

Xiaojian Shao (邵晓剑)

“莫为浮云遮望眼，风物长宜放眼量。
Dust Will Settle as We Go Along”

dpCoA tagSeq: Comments and Repsonses

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Published:

Recently, our dpCoA tagSeq method has been commented by Prof. Jeppe Vinther. We express our gratitude to Jeppe for his check on our bioinformatic analysis and pointing out the defects in our bioinformatic results.
Here are the links for the comment and our response.

Hepatitis C virus RNA is 5′-capped with flavin adenine dinucleotide

dpCoA tagSeq
NAD tagSeq

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Oral presentation in RNA forum

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Dr. SHAO gave a talk in an RNA forum - “RNA Biology and Health” hosted by the School of Life Science, Peking University.
His oral presentation is titled as :”TagSeq applies chemical biology methods to identify and characterize noncanonical RNA caps”.
The presentation mainly showed the development of dpCoA tagSeq and NAD tagSeq methods for identifying noncanonically capped RNAs.

RNA capping: biological functions?

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The Nobel Prize in Physiology or Medicine 2023 is awarded to the work on mRNA vaccine, which replaces uridine with pseudo-uridine in mRNA sequence, and it shows much milder immunue responses.
Recently, there are several crucial papers showing the roles RNA cappings play to mediate immune responses.

dpCoA tagSeq

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Published:

Our dpCoA tagSeq method has been published on Analytical Chemistry.